In the pharmaceutical field α-.β-cyclodextrin is more common. But with the deepening of research work found beta CD itself, there are water soluble low, renal toxicity, hemolysis and defects, especially the injection administration, toxicity, cause kidney damage, causing hemolysis and injection site necrosis. In order to overcome the shortcomings of the beta CD, synthesized a series of beta CD derivatives, which two very important derivatives are Hydroxypropyl beta cyclodextrin and sulfobutyl beta cyclodextrin. The two of them had the characteristics of high water solubility (50mg/100mL), low renal toxicity, small hemolysis, high safety and so on. Order of the size of hemolysis derivatives: two methyl beta -CD >β-CD > SBE-β-CD beta ≈H-β-CD.
Hydroxypropyl beta cyclodextrin as drug solubilization agent, stabilizer and absorption enhancers, has been widely used in oral solid preparation, injection, transdermal drug delivery preparation and rectum give medicine preparations. He was the first one to be used in the intravenous injection of cyclodextrin accessories, has been received by the United States as an injection of adjuvant.