Write to the clients:
We have meet many kinds of clients who maybe not trust us at firstÂ
and finally to be our honesty customers.Choose us,we will not let you down.Always  quick respond to your demands.Client is the god,not just talk.
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
GDF Basic Info.
Gdf-8 Alias: MSTN, Myostatin HMP
Gdf-8 Purity: >98%
Gdf-8 Specification: 1mg
Gdf-8 Storage: 2-8 degree centigrade refrigerator
Gdf-8 Package: 10 Vials/Kit
Gdf-8 Deliver:1 working day for ready goods 3~7 working days to your destination.
Gdf-8 Pacakge:1kit=10vials Alumnium foil+bubble+carton
Gdf-8 Customized:accepted.
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Myostatin (GDF-8) Introduction:
Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
Myostatin (GDF-8) is known as a potent inhibitor of muscle growth and development, and myostatin is also expressed early in the fracture healing process. The purpose of this study was to test the hypothesis that a new myostatin inhibitor, a recombinant myostatin propeptide, can enhance the repair and regeneration of both muscle and bone in cases of deep penetrant injury.
Effects:Â
PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.
Utilizations:
Mechano Factor (MGF) exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The problem with synthetic Mechano Factor (MGF) is that it is introduced intramuscularly and is water based so it goes into the blood stream.Â
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When used this way, Mechano Factor (MGF) only remains stable in the blood stream for a few minutes. Biologically produced MGF is made locally and does not enter the bloodstream.
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It is also short acting so stability is not an issue. By PEGylating the Mechano Factor (MGF) it is almost as efficient as local produced Mechano Factor (MGF) when used intramuscularly. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule.Â
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The polyethylene glycol groups protect the peptide but do not surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein.
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Write to the clients:
We have meet many kinds of clients who maybe not trust us at firstÂ
and finally to be our honesty customers.Choose us,we will not let you down.Always  quick respond to your demands.Client is the god,not just talk.
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
GDF Basic Info.
Gdf-8 Alias: MSTN, Myostatin HMP
Gdf-8 Purity: >98%
Gdf-8 Specification: 1mg
Gdf-8 Storage: 2-8 degree centigrade refrigerator
Gdf-8 Package: 10 Vials/Kit
Gdf-8 Deliver:1 working day for ready goods 3~7 working days to your destination.
Gdf-8 Pacakge:1kit=10vials Alumnium foil+bubble+carton
Gdf-8 Customized:accepted.
Â
Â
Myostatin (GDF-8) Introduction:
Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
Myostatin (GDF-8) is known as a potent inhibitor of muscle growth and development, and myostatin is also expressed early in the fracture healing process. The purpose of this study was to test the hypothesis that a new myostatin inhibitor, a recombinant myostatin propeptide, can enhance the repair and regeneration of both muscle and bone in cases of deep penetrant injury.
Effects:Â
PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.
Utilizations:
Mechano Factor (MGF) exhibits local effects in skeletal muscle and without cannot travel through the body without modification. The problem with synthetic Mechano Factor (MGF) is that it is introduced intramuscularly and is water based so it goes into the blood stream.Â
Â
When used this way, Mechano Factor (MGF) only remains stable in the blood stream for a few minutes. Biologically produced MGF is made locally and does not enter the bloodstream.
Â
It is also short acting so stability is not an issue. By PEGylating the Mechano Factor (MGF) it is almost as efficient as local produced Mechano Factor (MGF) when used intramuscularly. This is accomplished by surrounding part of the peptide with a structure of polyethylene glycol, which can be attached to a protein molecule.Â
Â
The polyethylene glycol groups protect the peptide but do not surround it completely. The active sites of the peptide are still free to do their biological function. In this case the shell is a negative charged shield against positively charged compounds that would affect the protein.
Â
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